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The ratiometric readout of RT only responds to GSH (10 mM), but not to glycine (10 mM), cysteine (100 M) or a series of ROS/RNS (100 M)
This has far-reaching effects, from maintaining healthy skin to supporting sharp cognitive function
Aging Cell 16(1):104112 Saleh R, Sallam H, Elsuity MA, Dutta S, Sengupta P, Nasr A (2024) Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects
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For instance, administering IGF-1R mAbs in cancer trials was reported to result in increased adverse events in younger populations 34 , including insulin resistance, possibly due in part to disruption of the somatotropic axis and associated deleterious effects of excess GH 41,42
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