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To guarantee a methodical approach to the search process and reporting of the results displayed in Supplementary Appendix S1 , the Preferred Reporting Items for Systematic Reviews and Meta-Analyses ( PRISMA ) checklist criteria were adhered to ( First, extensive searches were carried out across a number of databases in the Cochrane Library, Web of Science, PubMed, Google Scholar, and Science Direct
Subsequently, each system underwent independent simulations lasting 500 ns each (totaling 1.5 s per system) at 298 K, employing the Langevin thermostat with a time step of 0.2 fs (Supplementary Fig
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