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It should also be noted that there was a protocol deviation in the renal impairment study whereby participants were assigned to renal function groups using an eGFR value expressed in mL/min/1.73 m 2 instead of mL/min
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Clinical trials used structured titration schedules to minimize these side effects while allowing the body to adapt
Never adjust dosing without consulting your healthcare provider, as individualized titration balances efficacy with tolerability
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