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TMAO levels impact a set of functioning in the body
This means that they both cannot be made within the body and must be consumed in the diet
426 In contrast to AI/ML approaches that derive statistical correlations from data, mechanistic modeling builds mathematical representations based on underlying biological processes to explain and predict drug resistance
In pancreatic cancer, USP8 directly interacts with NRF2, deubiquitinating and stabilizing NRF2 to drive resistance to the antimetabolite gemcitabine [119, 153]
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