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From celebrity weight-loss stories to nonstop news segments, these medications have sparked a lot of curiosity about appetite, cravings, and blood sugar

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These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities

doi: 10.2174/1570163819666220315140736 471 MarcolinoLMCPereiraAHCPintoJGMamoneLAStrixinoJF

in fact, it can also favor cancer development due to its potential negative impact on anticancer immunity (366)