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Participants taking the highest dose of orforglipron (36 mg) experienced a mean weight loss of 7.3 kg , or 7.9%, compared with 1.3 kg or 1.6% in the placebo group

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Upon binding to its own receptor, IGF-1 signals the pituitary gland to secrete less growth hormone and, at the same time, tells the hypothalamus to secrete less GH-releasing hormone

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