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Symptoms that persist beyond the initial 812 weeks of therapy, worsen over time, or significantly impair nutritional intake warrant further evaluation
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Regarding the signaling pathway that is involved in autophagy induction, the present study demonstrated that PFOS induced ERK1/2 and ER stress activation, leading to autophagy induction with an increased expression of Beclin and LC3BII
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(54) Taken together, these studies suggest that protein intake may need to be reduced along with calories to lower IGF-1 levels
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