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Evidence and Research Comparison# Mazdutide Research# Mazdutide was approved in China in June 2025 for weight management, making it the first GLP-1/glucagon dual agonist to receive regulatory approval anywhere: Phase 3 obesity (China) : Up to 20.1% body weight reduction at the 9 mg dose over 60 weeks

Namun, saat ini banyak uji klinis juga telah membandingkan efektivitas liraglutide dan semaglutide, yang sama-sama merupakan agonis reseptor GLP-1.[1-3] Pada bulan Juni 2021, FDA menyetujui injeksi semaglutide 2,4 mg secara subkutan dengan dosis 1 kali seminggu sebagai tambahan terapi diet rendah kalori dan aktivitas fisik