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Recently, three new axes have been identified, emphasizing the role of the kidney in this picture (22): The ACE2/ANG(1-7)/Mas receptor pathway (23, 24): Ang-(1-7) binds to the G protein-coupled receptor Mas, which is expressed in renal proximal tubular cells, afferent arterioles, cardiac myocytes, and neuronal cells

Oridonin Effectively Reverses Cisplatin Drug Resistance in Human Ovarian Cancer Cells via Induction of Cell Apoptosis and Inhibition of Matrix Metalloproteinase Expression

[57] It suppresses appetite through a dual mechanism: it directly stimulates anorexigenic (satiety-inducing) neurons that express proopiomelanocortin (POMC) and cocaine-and amphetamine-regulated transcript (CART), while simultaneously inhibiting orexigenic (appetite-inducing) neurons that express AgRP and NPY

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Moreover, shikonin reversed gemcitabine tolerance in a xenograft model of pancreatic cancer via modulation of the NF-B signaling pathway (429)