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TGR5 activity appears to not have been lost in type 2 diabetic humans whereby the infusion of CCK, or rectal taurocholate, causes GLP-1 and insulin release via the TGR5 axis in colonic L-cells and pancreatic -cells respectively (341, 342)
The larger unknown risk is that tens of millions of temporary GLP-1 users develop what is a real issue for many traditionally processed food products a sudden aversion to ultra-processed flavor profiles themselves
Most cases improve with simple diet and lifestyle changes
Nevertheless, diabetes specialists and ophthalmologists may want to monitor patients carefully for visual symptoms
This allows better absorption without interference from food
