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In mice, risperidone treatment led to gut bacterial changes similar to those seen in obesity more Firmicutes, fewer Bacteroidetes and a 16% drop in resting energy expenditure, especially from anaerobic (non-oxygen-requiring) metabolism
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Severe cases, it says, progress to electrolyte imbalance, hypotension, and acute kidney injury if fluid losses go unmanaged
PMID 17408840
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