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Research by Pickart and Margolina (2018) in the International Journal of Molecular Sciences showed that GHK-Cu modulates approximately 31% of human gene expression, activating 59% of affected genes and suppressing 41%

Chemical research in toxicology 25 , 94100, doi: 10.1021/tx200242a (2012)

186 This suggests that targeting USP20 may mitigate chemotherapy resistance and promote ferroptosis in HCC patients, and explains why DNA damage therapy often leads to treatment resistance