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Patients with established cardiovascular disease should receive a pharmacological treatment intensification with an agent that has demonstrated benefit in cardiovascular safety studies: In patients with pre-existing atherosclerotic cardiovascular disease (ASCVD), a GLP-1 receptor agonist, or SGLT-2 inhibitor with characterized cardiovascular safety should be used
Data from only three groups (vehicle, AMG 133 0.25 mg kg 1 and AMG 133 0.75 mg kg 1 ) are reported and discussed in this publication
The rate of heart attack was 1.5% vs 6.1 %, while the risk of subsequent stroke was the same (6%) in those with and without the GLP-1 inhibitor
A pill press seized in Virginia
Emerson et al
