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For now, as shortages resolve, small compounders can continue to make patient-specific alternatives on the basis that medicine isnt one-size-fits-all
et al (2002)
That is not unique to Retatrutide
On the other hand, the recent bidding war between Pfizer and Novo Nordisk for Metsera (NASDAQ: MTSR) GLP-1s provides another signal regarding the markets direction
The substitution of Ala8 in GLP-1 by Gly8 in exendin-4 contributes to enhanced DPP-4 resistance ( Interestingly, until now, primarily long-chain peptides with 3339 amino acids have been developed as GLP-1RAs, which also carry a cost burden
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