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These might represent the highest-risk patients enrolled in SELECT, but youre modifying the relative risk among the people who are going to have these early events. The first significant difference in major adverse cardiovascular events between treatment arms was seen at 20 days

Fluid and mineral balance is a parallel concern

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Notably, as these studies were largely open-label with varying intensities of lifestyle intervention and control conditions, they are better suited as evidence for strategic feasibility rather than as direct equivalents to placebo-controlled trials