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If you view sleep as part of aging well, this article on longevity peptides may be useful

Castro says

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist

4 Another study in obese male rats found that while a calorie-reduced diet alone led to decreased trabecular thickness and impaired bone remodeling in the tibia and spine, adding moderate treadmill exercise improved tibial BMD and reduced bone resorption, as shown by lower CTX levels and fewer osteoclasts

Not just gradual thinning Aggressive, relentless shedding that got worse every week