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Histone methylation fundamentally occurs on arginine and lysine residues of the core histone protein via histone methyltransferase (HMT)
Doses are not equivalent across routes, so published research treats each route's dosing separately
N Engl J Med 385(16):14511461 Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF et al (2022) Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction
many patients transition from injections to oral maintenance once levels are corrected and absorption is adequate
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