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Research has shown that an imbalance between Th1 and Th2 cells is associated with the pathogenesis of osteoarthritis, contributing to inflammation and disease progression (116)
To further explore the in vivo functions of Keap1 in adult MuSCs, we first generated a tamoxifen (TMX)-inducible MuSC-specific Keap1 knockout mouse strain (designated as Keap1 conditional knockout or Keap1 cKO thereafter) using the CreER/LoxP system
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