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PMID 24267355

IGF-1R, the insulin receptor and the receptor for IGF-2 sit in an overlapping ligand space, and because both receptors are assembled from half-receptors in the same compartment, cells expressing both will also display IR/IGF-1R hybrid receptors composed of one alpha-beta half of each

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Zimmerman HJ, Ishak KG: Valproate-induced hepatic injury: analyses of 23 fatal cases