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This review will be of great interest to those working in materials science, nanotechnology, and especially to those in biomedical engineering and translational medicine, which will not only serve as an up-to-date compilation of achievements in this area, but also provide a generalized guideline for BBB regulation and rational design of targeted drug delivery systems

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Shaking creates foam and shear stress, which can damage delicate peptide structures

No effect on GHR signaling This is a key point that distinguishes AOD-9604 from other GH-derived peptides

Healthy liver function is crucial for overall well-being