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The brain, mainly the hypothalamus, integrates these gut-derived signals, along with others, to coordinate the regulation of food intake, energy expenditure, and glucose homeostasis 14,15
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Historical reason: the original 503A and 503B compounding pharmacies that started compounding semaglutide in 2022 used B12 as a "marker" so patients and providers could visually distinguish their compounded product from FDA-approved Ozempic, which is always clear
Zhang C, Liu Z, Wang F, Zhang B, Zhang X, Guo P, et al
Elevated levels of that amino acid are correlated to a higher risk for dementia, heart disease, and stroke, per Cleveland Clinic
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