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doi: 10.1007/s13318-022-00767-4 50 XuNLuoHLiMWuJWuXChenLet al

In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]