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Neurochem Int 55:136

FIGURE 25 FIGURE 26 FIGURE 27 SAR studies contributed to the design of 35 novel dual inhibitors, among which four compounds, compounds 87 (compound 18) , 88 (compound 19) , 89 (compound 20) , and 90 (compound 21) exhibited comparable binding affinities to PDE1/10A

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44.99 AHK-Cu is a copper-binding tripeptide structurally related to GHK-Cu, sharing the copper chelation capacity that defines this peptide family while presenting a distinct amino acid sequence