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These findings suggest that Gln metabolism should be understood more appropriately as a metabolic network node, whose effects depend on nutrient availability, mitochondrial functional status, and its mode of coupling with other metabolic pathways, such as glycolysis and TCA cycle interruption and anaplerosis
Additionally, S14, S17, and S18 of GLP-1 interact with the residues of ECL2 like C 296 , W 297 , T 298 , R 299 and N 300 , whereas no such interactions are observed for SR18
Diabetologia 2010, 53, 22562263
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