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For dietary deficiency (vegans, low meat intake) high-dose oral B12 supplements (1,0002,000 mcg daily) are equally effective as injections for correcting dietary deficiency in most people
That number gets even worse if you have hypothyroidism (up to 50% of these patients have B12 deficiency)
What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have
Oral vitamins must get broken down by the GI tract (through stomach, intestines) then go through the liver for metabolizing
Food and Drug Administration (FDA) about these findings and recommends that people using these untested products contact their physicians for advice and discussion on alternative treatment options
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