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Advanced beta-cell dysfunction in long-standing type 2 diabetes can limit GLP-1 efficacy

This suggests that the reduction in blood pressure could be a direct effect of the GLP-1 mimetic

While this is a key research area, we propose that further investigations should verify whether GLP-1RAs may also affect cognitive and behavioral symptoms seen in psychosis, as suggested by their potential to influence neurobiological (for example, immune function) and neuropsychological (for example, reward) mechanisms that are known to be disrupted in psychotic illness

Prieto et al

Food and Drug Administration (FDA) approves the use of semaglutide for weight loss if you meet one of two criteria