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Its ongoing use in laboratory literature reflects research interest only and does not indicate therapeutic, cosmetic, or clinical benefit
In a phase II study of the long-acting GLP-1RA efpeglenatide (4 mg once weekly, 6 mg once weekly, 6 mg once every 2 weeks, and 8 mg once every 2 weeks), patients with obesity and without diabetes had statistically significant reductions in body weight compared with placebo after 20 weeks of treatment (differences in least squares means were 6.3 to 7.2 kg
Allergic reactions to semaglutide or other similar drugs (GLP-1s)
Perceived stress mediates the relationship of body image and depressive symptoms in individuals with obesity
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Although the exact binding sites remain unclear and have not been directly confirmed by structural analyses, these findings enhance our understanding of how GLP-1-related peptides can selectively modulate TRPV1 without broad systemic effects
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