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Tumors with inherited or somatic deficiencies in HRR genes, such as BRCA1, BRCA2, PALB2, and RAD51, exhibit synthetic lethality to PARPis, including olaparib, rucaparib, niraparib, and talazoparib, which have shown durable efficacy in BRCA-mutant breast, ovarian, and prostate cancers

Chromium (VI) did not significantly modify the formation of ceramides

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Still, researchers caution that findings are largely preliminary and drawn from small cohorts rather than large, sex-stratified clinical trials