A hierarchical testing strategy was used in PIONEER 5 and 6
This initiative follows a rise in U.K

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Doctors Across the Country Are Warning GLP-1 Users About "Ozempic Feet": What It Is and Who Is at Risk Podiatrists across the United States are seeing a new pattern in their exam rooms: patients on Ozempic, Wegovy, Mounjaro, or Zepbound coming in with feet that have suddenly become bonier, looser, and sometimes painful, a condition that is being called "Ozempic feet." Doctors across the country have reported seeing patients whose significant weight loss has left their feet looking bonier, looser, or more deflated due to a reduction in fat tissue, according to a NewsNation report published July 1112, 2026, that went viral nationally
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