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In ATTAIN-MAINTAIN, patients who switched from semaglutide or tirzepatide to orforglipron broadly maintained their losses, which is a sensible secondary commercial position
Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the bloodbrain barrier
The findings align with recent studies that showed similar results when comparing SGLT2 inhibitors and GLP-1RAs in patients with type 2 diabetes, where the NAFLD status was unknown [30]
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