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These include unexplained fatigue or energy changes, significant mood alterations, palpitations or irregular heartbeat, increased sensitivity to heat or cold, changes in bowel habits beyond expected medication side effects, unexplained hair loss, or skin changes

The Gq pathway begins with the coupling to phospholipase C (PLC), which converts phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG)

Back Lunenfeld-Tanenbaum Research Institute (18 Dec 2023) 'From diabetes drug to anti-inflammation powerhouse: The unexpected evolution of GLP-1', News: Medical Life Sciences

The original application, based on the earlier HOPE-2 study, received a Complete Response Letter last year for lack of substantial evidence of effectiveness