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Nonetheless, the common theme is that GLP-1 RAs tend to push the microbiome in a direction associated with metabolic health (greater abundance of SCFA-producing and mucus-associated bacteria, lower abundance of pro-inflammatory organisms), although substantial changes may require prolonged therapy ( Microbiota-derived metabolites and gut hormone signaling SCFAs and GLP-1 crosstalk The gut microbiota and its derived metabolites play a central role in modulating host metabolism, immune function, insulin sensitivity, and overall health ( Among these metabolites, SCFAs (primarily acetate, propionate, and butyrate) act as critical signaling molecules linking microbial fermentation with host energy regulation