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Description

As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure

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Quick Reference: Injection site reactions: 15-25% (mild, resolve in 2-24 hours) Nausea: 5-10% (transient, first week) Dizziness: 3-7% (occasional, brief) Serious events: Zero documented in 100+ animal studies Typical dose: 250-500 mcg/day SubQ

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Treatment of Gclc L-KO with GSH-ee reduced the observed increased Nrf2 target gene expression to basal levels in a dose-dependent manner (Fig

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