A couple of studies found no benefits of B12 for lowering homocysteine in HD patients, one used oral B12, 2000 g three times per week for 6 weeks, 55 the other used methyl-B12 i.m
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Careful monitoring of blood pressure is recommended when initiating therapy in hypertensive patients, and those with baseline low blood pressure should use B-containing injections cautiously
doi: 10.3389/fmars.2024.1404661 Summary Keywords astaxanthin, thermal stress, anti-oxidative, Micropterus salmoides , glutathione metabolism, Keap1-Nrf2 signaling pathways Citation Sun Y, Zong W, Wang J, He J, Zhang J and Han T (2025) Astaxanthin enhances antioxidant capacity to alleviate thermal stress-induced liver inflammation in largemouth bass ( Micropterus salmoides ): a multi-omics insight into glutathione metabolism remodeling
These findings emphasize the importance of preserving enzymatic antioxidant defenses in combating DOX-induced cardiotoxicity and the superior efficacy of metformin and CoQ10 combination pre-treatment in improving cellular redox homeostasis