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[11] [12] DAP pathway [edit] The DAP pathway is found in both prokaryotes and plants and begins with the dihydrodipicolinate synthase (DHDPS) (E.C 4.3.3.7) catalysed condensation reaction between the aspartate derived, L-aspartate semialdehyde, and pyruvate to form (4 S )-4-hydroxy-2,3,4,5-tetrahydro-(2 S )-dipicolinic acid (HTPA)
Disulfide bonds are relatively stable under physiological conditions but undergo selective cleavage in the tumor microenvironment (TME), minimizing premature drug release [53]
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Patients with type-1 diabetes are more affected by COVID-19
