Because of this extended half-life, missing your injection by two days does not cause an immediate drop in blood levels or loss of therapeutic effect
Zhang, Q.-Y., Yan, Z.-B., Meng, Y.-M., Hong, X.-Y., Shao, G., Ma, J.-J., et al
Though this has been shown to lead to larger variability, numerous simulation papers have shown that this leads to a more conservative estimate and allows for the most generalizable estimate of treatment effect
Were really waiting on more of the clinical-trial evidence to come in, and there are a number of studies, mine and others, ongoing right now
The extended half-life of approximately 7 days is due to albumin binding and resistance to DPP-4 degradation, enabling convenient once-weekly dosing [1]