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During embryonic development, pluripotency transitions from a nave to a primed state, and modeling the reverse primed-to-nave transition (PNT) provides a valuable framework for investigating pluripotency regulation

The neurogenic changes P21 induces may persist beyond the treatment period

TB-500 binds monomeric G-actin via the LKKTETQ motif, modulating the actin pool available for cytoskeletal remodeling and cell migration

In vitro (made in the lab not on real people) and animal studies have shown that it may produce hormonal (estrogen-like) effects