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The most dramatic result (mice returning to a body composition indistinguishable from lean age-matched animals) came from combining the inhibitor with a low-fat diet switch, and that study did not include a drug-alone arm
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The side effects are mostly in the Gastrointestinal area: Nausea and vomiting Diarrhea or constipation Abdominal pain Dizziness, Tachycardia, Infections, Headaches being lesser reported
Compared with conventional GLP-1 receptor agonists, such as liraglutide and semaglutide, tirzepatide has demonstrated superior efficacy in body weight control in several phase III clinical trials, with average weight reductions exceeding 20% in some study populations (15)
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