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Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time

As a result, Escitalopram is often prescribed at lower doses than Citalopram and may have a slightly more favorable side-effect profile for some patients

To view a copy of this licence, visit About this article Cite this article Lingampelly, S.S., Naviaux, J.C., Heuer, L.S

If side effects remain problematic, specific supplements may help manage individual symptoms

This pharmacokinetic profile, combined with its amphiphilic character (allowing it to cross the blood-brain barrier), has sustained interest in DSIP as both a research tool and a subject of investigation in its own right