This cascade promotes angiogenesisnew blood vessel formationwhich delivers oxygen and nutrients to healing tissues
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Exceptions were observed when Liraglutide at 10 nM enhanced the proliferation of hMSC pretreated with LPS to mimic an inflammatory setting [4], and in experiments performed by Wang et al., where Liraglutide at 10 nM showed no effect on the proliferation of human bone marrow-derived stem cells (hBMSC) [21]
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MMP-9 expression is up-regulated by macrophages and is responsible for degrading extracellular matrix proteins including collagen, which results in thinning of the plaque's fibrous cap