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The dose escalation schedule recommended in the FDA prescribing information (starting at 2.5 mg and increasing gradually) is designed to minimize side effects
Some had been started on a GLP-1 medication
Significant weight lossdefined as 5% or more of starting body weightusually occurs by week 12 in responders
Phentermine's sympathomimetic stimulation combined with semaglutide's direct cardiovascular effects creates compounded stress on the heart, particularly in people with existing hypertension or arrhythmia history
Signal Transduction and Targeted Therapy , 7 (1)
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