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Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity
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Meal-stimulated change in GLP-1 at baseline was added as a covariate to the primary outcome model in a prespecified secondary analysis, to assess the relationship with %WL at 68 weeks
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