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The synergy between the two receptor pathways is present even at low doses, which is an argument for tirzepatide-based microdosing over semaglutide-based microdosing from a metabolic standpoint

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If nausea is persistent or severe enough to consistently prevent eating or drinking, it is worth mentioning to a healthcare provider, who may adjust the dose or suggest additional strategies

Treatment usually starts at 0.25 mg once weekly for 4 weeks, then increases to 0.5 mg