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If constipation does not improve within a week of appropriate laxative use, or if red flag symptoms develop (such as rectal bleeding, unexplained weight loss, or severe pain), urgent medical review is essential
The treatment led to substantial, sustained weight loss versus placebo and maintained improvements in cardiometabolic parameters
Dosing is usually increased gradually
Brattstrm L, Lindgren A, Israelsson B, Andersson A, and Hultberg B (1994)
When you lose 1520% of your body weight in six months, you're not just shedding fat
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