tirzepatide insulin resistance in Obesity-Related Obstructive Sleep Apnea: Beyond Weight Loss Toward Disease Modification? Novel Dual Incretin Receptor Agonists

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Moreover, the regulation of sodium and calcium homeostasis in cardiomyocytes and coronary endothelium is directly translated into improved contractility and relaxation of the heart ( Diuretic and natriuretic effects of SGLT2 inhibitors contribute to the reduction of intravascular volume and decrease in blood pressure, lowering afterload, improving cardiac efficiency, and reducing ventricular mass index (Mazidi et al., 2017

More concerning still, the prevalence of severe obesity, defined as a BMI 35 kg/m 2 with at least one comorbidity or a BMI 40, was 9.7% [6]

Alternatives include other SGLT2 inhibitors and drugs from other classes of medicines that lower blood sugar