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Tirzepatide causes thyroid C-cell tumors in rats, and although its unknown whether tirzepatide causes thyroid C-cell tumors in humans, it is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Peripherally, pancytopenia is most often observed, but only 12 of the major cell types (erythrocytes, leukocytes, platelets) may be depressed in some cases
GLP-1 + GIP does both
Initial onset and peak symptoms: Most patients experience flu-like symptoms within the first few days to two weeks of starting GLP-1 therapy or after dose escalation
GLP-1 receptor agonists, originally developed for diabetes management, have revolutionized weight loss treatment by targeting appetite and metabolism
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