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Clin Ther 2010;32(4):710-713

And I was explaining

Starting at a lower dose and increasing gradually can help reduce GI side effects, including diarrhea

Moreover, it suggested that PAT-induced apoptosis is mediated through the mitochondrial pathway without the involvement of p53 [12]

Q180 (TM3) is directly above the Na + ion and engaged in a hydrogen bond with the sodium-coordinating N210 (TM4) while also forming an inter-helical interaction to TM1 containing N32