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Clinicians might need to adjust laxative dosage to prevent constipation or overly delayed gastric emptying, balancing the effects to maintain symptom relief in IBS-C patients

AMPK, TSC2, PTEN, and IGF-BP3, which are regulated by p53, negatively regulate the activity of the IGF-1-AKT-mTOR pathway upon exposure to stress

Rigorous clinical trials like SOLSTICE can help us evaluate oral medications that may be just as effective for patients with diabetes while overcoming these limitations." Elecoglipron was developed specifically for the treatment of type 2 diabetes

In AWARD-1, the once-weekly injectable GLP-1 agonist demonstrated superior glycemic control compared with twice-daily exenatide (Byetta) in type 2 diabetic patients not adequately controlled with full-dose metformin and pioglitazone