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Using a target trial emulation framework, researchers analyzed Truveta Data and compared adults with alcohol use disorder (AUD) and either type 2 diabetes or obesity who started a newer GLP-1 RA (semaglutide, tirzepatide) to similar individuals starting alternative medications

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As these patients were most likely classified as moderate progressors, the results suggested that 50 mg methylcobalamin injections could be beneficial for patients with ALS in the early stage and with moderate progression rate, the researchers wrote

However, as the concept of ferroptosis had yet to be established, a definitive connection could not be drawn ( Trypanosoma cruzi tryparedoxin peroxidase results in lethal iron-dependent lipid peroxidation, leading to ferroptosis, with mitochondrial iron playing a pivotal role