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Medications including metformin, proton pump inhibitors, and H2-receptor antagonists may reduce absorption of B12, potentially prolonging the time to clinical improvement

An injectable form is considered far more effective than topical, as it works systemically and bypasses the top layer of the skin

Cagrilintide cant be codissolved with semaglutide so NVO will commercialize CagriSema in a dual-chamber injection device and thus sales potential is TBD, according to the Leerink note

Cagrilintide + semaglutide yielded 17.1% weight loss compared to 9.8% with semaglutide alone

These findings help inform how targeting multiple hormone pathways may affect appetite regulation and metabolism in controlled study settings